Intelligent LNP Synthesizer
This microfluidic platform offers advantages such as highly controllable particle size, monodispersity, reproducibility between batches, low sample consumption, and ease of operation, enhancing the efficiency of pre-formulation screening for customers.
- Highly controllable and homogeneous particle size
- High batch repeatability
- Intelligent Control
- Low cost of consumables
- Easy to operate
- Efficient operation
More About This Item
Description
In the process of preparing LipidNanoparticle (LNP), the key step is to mix phospholipids and buffer (the buffer contains mRNA, siRNA and other biomolecules) at high speed in the microfluidic chip to self-assemble into LNPs. the microfluidic LNP preparation platform has the advantages of highly controllable particle size and monodispersity, high reproducibility between batches, low sample consumption and easy operation, which can greatly improve the efficiency of customer’s pre-formulation screening. The microfluidic LNP preparation platform has the advantages of highly controllable particle size and monodispersity, high reproducibility between batches, low sample consumption, easy operation, etc., which can greatly improve the efficiency of customers’ pre-formulation screening.
Features
Highly controllable and homogeneous particle size
- Particle size is controllable from 40 nm to 200 nm with a monodispersity (PDI) below 0.02.
High batch repeatability
- Fully automated system with no plumbing connections, no start-up and no cleaning, eliminating variability from batch to batch.
Intelligent Control
- It can automatically detect abnormal conditions such as chip clogging and leakage, and stop the machine automatically, saving users’ valuable raw materials.
Low cost of consumables
- Chips are *highly strong, resistant to 50 atmospheres, and can be cleaned and reused.
Easy to operate
- No need for external computer, full touch screen configuration, experimental parameters can be loaded or saved, and preparation can be started within 30 seconds of power on.
Efficient operation
- The equipment is compatible with domestic and foreign disposable syringe models, with a single running time of 9~40s, and hundreds of formulations can be screened in a day.
Intelligent Control
- Built-in pressure and position sensors for precise control of sample flow rate.
- Dual-channel independent control with flexible setting of flow rate ratio.
- Automatically detects abnormal conditions such as chip clogging and leakage, and automatically stops the machine.
- Rapidly reaches the set flow rate and drastically reduces the volume of pre-waste liquid.
Features in Chinese
粒径高度可控，粒径均一
- 粒径从40 nm到200 nm可控，单分散度（PDI）低于0.02
批次重复性高
- 全自动化系统，无管路连接，无需启动和清洁，消除不同批次的可变性
智能控制
- 可自动检测芯片堵塞和泄漏等异常情况，自动停机，节约用户宝贵原料
耗材成本低
- 芯片强度*高，耐压50大气压，可经过清洗重复使用
操作简易
- 无需外接电脑，全触屏配置，实验参数可加载或保存，开机30秒内即可开始制备
运行高效
- 设备兼容国内外一次性注射器型号，单次运行时间 9~40s，一天内可完成上百种配方筛选。
智能控制
- 内置压力与位置传感器，精准控制样品流速.
- 双通道独立控制，流速比灵活设置.
- 自动检测芯片堵塞和泄漏等异常情况，自动停机.
- 快速到达设定流速，大幅度减少前废液体积.
LNP Medium Volume Hybrid Chip
- LNP particle size: 40~200 nm.
- Total flow rate range: 0.04 ~ 40 mL/min (ethanol and water set at 1:3).
- Fishbone mixing structure, laminar mixing time <3 ms.
- COC material, pressure resistance over 50 Bar, no risk of leakage and clogging.
- No tubing is required, and the chip is connected directly to the syringe.
LNP中体积混合芯片
- LNP粒径：40~200 nm
- 总流速范围：04 ~ 40 mL/min（ 乙醇和水按照1:3设置）.
- 鱼骨形混合结构，层流混合时间＜3 ms
- COC材质，耐压 50 Bar 以上，无泄漏堵塞风险.
- 无需管路，芯片与注射器直接连接。
LNP Encapsulation Kit
- Compound phospholipids and buffers, ready to use.
- Can wrap mRNA mRNA, siRNA, CRISPR/Cas9 and other nucleic acids.
- >95% transfection rate.
- Low toxicity.
- A complete experimental program is available.
LNP包封试剂盒
- 复方磷脂和缓冲液，即开即用.
- 可包裹 mRNA mRNA，siRNA，CRISPR/Cas9 等核酸.
- >95% 的转染率.
- 低毒性.
- 可提供完整实验方案。
